Hydrochloric Acid → 2-[(3RS)-3-carbamoylpiperidin-1-yl]-2-iminoethylmercaptan hydrochloride

HRID 622429노트

반응식

HRID 622429 반응식
P(=[S:5])([O-])([O-])[O-].[Na+].[Na+].[Na+].Cl.[C:10]([CH:13]1[CH2:18][CH2:17][CH2:16][N:15]([C:19](=[NH:22])[CH2:20][Cl:21])[CH2:14]1)(=[O:12])[NH2:11].Cl>O>[ClH:21].[C:10]([CH:13]1[CH2:18][CH2:17][CH2:16][N:15]([C:19](=[NH:22])[CH2:20][SH:5])[CH2:14]1)(=[O:12])[NH2:11]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 9877537Trisodium thiophosphateHCID 212929612-[(3RS)-3-carbamoylpiperidin-1-yl]-2-iminoethylchloride hydrochloride

생성물 1

HCID 212929852-[(3RS)-3-carbamoylpiperidin-1-yl]-2-iminoethylmercaptan hydrochloride수율 105.9%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

1.43 g of trisodium phosphorothioate were added to an ice-cooled solution of 2.04 g of 2-[(3RS)-3-carbamoylpiperidin-1-yl]-2-iminoethylchloride hydrochloride in 9.7 ml of water, and the mixture was stirred at room temperature for one hour. 7.9 ml of 1N hydrochloric acid were then added, and the mixture was heated at 50° C. for 30 minutes. The reaction mixture was then worked up in the same manner as in Example 3(2) to give 2.0 g of 2-[(3RS)-3-carbamoylpiperidin-1-yl]-2-iminoethylmercaptan hydrochloride.

후처리

  1. temperaturethe mixture was heated at 50° C. for 30 minutes

출처 및 근거

ORD 기록
ord-a8211e0cf8f2420599fee0cf2bb665cb
출처 데이터셋
uspto-grants-1988_09
특허 번호
US04771046

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