Benzene, [1-[(trimethylsilyl)oxy]ethenyl]- → 2-Phenylacetophenone

HRID 622817

반응식

HRID 622817 반응식
[C:1]1([C:7]([O:9][Si](C)(C)C)=[CH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.F[B-](F)(F)F.[C:19]1([N+]#N)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>N1C=CC=CC=1.C(OCC)C>[C:1]1([C:7]([CH2:9][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 2

HCID 117406Benzene, [1-[(trimethylsilyl)oxy]ethenyl]-HCID 5284485Benzenediazonium tetrafluoroborate

생성물 1

HCID 99482-Phenylacetophenone수율 70.1%

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 3283Diethyl Ether용매

반응 조건

온도
0 °C

실험 절차

0.97 mmol of (1-phenylethenyl)oxytrimethylsilane was placed in a 20-ml flask, followed by the addition of 3 ml of pyridine as a solvent. 1.3 mmol of benzenediazonium tetrafluoroborate was added to the flask. The resulting mixture was stirred at 0° C. in a nitrogen atmosphere for 2 hours. The reaction mixture was diluted with diethyl ether and washed with 1.5N hydrochloric acid, water and a saturated aqueous solution of a common salt, successively. The organic phase was dried over magnesium sulfate and distilled under a reduced pressure to remove the solvent. The obtained oily mixture was subjected to silica gel thin-layer chromatography to obtain 0.68 mmol of benzyl phenyl ketone.

후처리

  1. washwashed with 1.5N hydrochloric acid, water
  2. dry with materialThe organic phase was dried over magnesium sulfate
  3. distillationdistilled under a reduced pressure
  4. customto remove the solvent

출처 및 근거

ORD 기록
ord-62b15808900d478c86f8bda1ba4381fa
출처 데이터셋
uspto-grants-1988_09
특허 번호
US04772714

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