Homoallyl bromide → HCID 178448195, 화합물

HRID 623168

반응식

HRID 623168 반응식
[Mg:1].Br[CH2:3][CH2:4][CH:5]=[CH2:6].Br[CH:8]=[CH:9][CH2:10][CH3:11].O1CCOCC1>C1COCC1.BrC(Br)C>[CH2:3]([Mg:1][CH2:11][CH2:10][CH:9]=[CH2:8])[CH2:4][CH:5]=[CH2:6]

참가 물질

7

반응물 4

HCID 21241Homoallyl bromideHCID 312751,4-DioxaneHCID 359451-Bromobut-1-eneHCID 5462224Magnesium

생성물 1

HCID 178448195HCID 178448195, 화합물

시약·촉매·용매 2

HCID 112011,1-Dibromoethane촉매HCID 8028Tetrahydrofuran용매2회

실험 절차

A mixture of magnesium turnings (0.5 g, 0.02 mole) and dry THF (5 mL) were placed in a dry, three-necked round-bottomed flask under argon. To this was added dropwise a solution of 2.3 g (0.7 mole) of 4-bromobutene in 5 mL of dry THF. After about 1/3 of the bromobutene was added, the reaction had not initiated. Two drops of dibromoethane was added and the reaction heated to reflux until Grignard formation was initiated. Heating was stopped and the remainder of the halide was added dropwise to maintain a gentle reflux. After all of the halide was added, the reaction was heated briefly then treated with 1.5 g (0.017 mole) of dioxane with stirring. An immediate white precipitate was formed. This suspension was used in the next step without further purification.

후처리

  1. temperaturethe reaction heated
  2. temperatureto reflux until Grignard formation
  3. temperatureHeating
  4. temperatureto maintain a gentle reflux
  5. temperaturethe reaction was heated briefly
  6. customAn immediate white precipitate was formed
  7. customThis suspension was used in the next step without further purification

출처 및 근거

ORD 기록
ord-4be068d7828742fc8009d0367e22ccd0
출처 데이터셋
uspto-grants-1988_09
특허 번호
US04772755

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