Iodoethane → Methyl 6-chloro-5-ethoxynicotinate

HRID 623481노트

반응식

HRID 623481 반응식
[Cl:1][C:2]1[C:11]([OH:12])=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][N:3]=1.I[CH2:14][CH3:15]>>[Cl:1][C:2]1[C:11]([O:12][CH2:14][CH3:15])=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][N:3]=1

참가 물질

3

반응물 2

HCID 6340IodoethaneHCID 46941479Methyl 6-chloro-5-hydroxynicotinate

생성물 1

HCID 87426133Methyl 6-chloro-5-ethoxynicotinate수율 43%

실험 절차

The title compound is prepared in 43% yield (0.68 g, a white solid) from methyl 6-chloro-5-hydroxynicotinate (1.37 g, 7.28 mmol) and iodoethane instead of iodomethane by the similar manner in Step-2 of Amine-4.

출처 및 근거

ORD 기록
ord-21118288522543c79e11ceadb98f768d
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09302991B2

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