Isobutyryl chloride → 3-isobutyramido-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)picolinamide

HRID 623610

반응식

HRID 623610 반응식
[NH2:1][C:2]1[C:3]([C:8]([NH:10][CH:11]([C:13]2[CH:14]=[N:15][C:16]([O:19][CH2:20][C:21]([F:24])([F:23])[F:22])=[CH:17][CH:18]=2)[CH3:12])=[O:9])=[N:4][CH:5]=[CH:6][CH:7]=1.[C:25](Cl)(=[O:29])[CH:26]([CH3:28])[CH3:27]>>[C:25]([NH:1][C:2]1[C:3]([C:8]([NH:10][CH:11]([C:13]2[CH:14]=[N:15][C:16]([O:19][CH2:20][C:21]([F:24])([F:23])[F:22])=[CH:17][CH:18]=2)[CH3:12])=[O:9])=[N:4][CH:5]=[CH:6][CH:7]=1)(=[O:29])[CH:26]([CH3:28])[CH3:27]

참가 물질

3

반응물 2

HCID 62325Isobutyryl chlorideHCID 675097703-amino-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)picolinamide

생성물 1

HCID 675093203-isobutyramido-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)picolinamide수율 52%

실험 절차

The title compound is prepared in 52% yield (15 mg) from 3-amino-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)picolinamide (24 mg, 0.071 mmol, Step-1, single enantiomer) and isobutyryl chloride (23 mg, 0.21 mmol) by the similar manner in Step-2 of Example-8.

출처 및 근거

ORD 기록
ord-9987dc7d2e40475584bab7909549f5ce
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09302991B2

연결된 노트

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