Isobutyryl chloride → 2-isobutyramido-N-((6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)pyrimidine-4-carboxamide
반응식
[NH2:1][C:2]1[N:7]=[C:6]([C:8]([NH:10][CH2:11][C:12]2[CH:13]=[N:14][C:15]([O:18][CH2:19][C:20]([F:23])([F:22])[F:21])=[CH:16][CH:17]=2)=[O:9])[CH:5]=[CH:4][N:3]=1.[C:24](Cl)(=[O:28])[CH:25]([CH3:27])[CH3:26]>>[C:24]([NH:1][C:2]1[N:7]=[C:6]([C:8]([NH:10][CH2:11][C:12]2[CH:13]=[N:14][C:15]([O:18][CH2:19][C:20]([F:22])([F:23])[F:21])=[CH:16][CH:17]=2)=[O:9])[CH:5]=[CH:4][N:3]=1)(=[O:28])[CH:25]([CH3:27])[CH3:26]참가 물질
3
실험 절차
The title compound is prepared from 2-amino-N-((6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)pyrimidine-4-carboxamide (17 mg, 0.05 mmol, Step-1) and isobutyryl chloride (17 mg, 0.16 mmol) according to the procedure similar to that described in Step-2 of Example 8.
출처 및 근거
- ORD 기록
- ord-5fa9187f33824cb286452973aeb75508
- 출처 데이터셋
- uspto-grants-2016_04