HCID 68283466, 화합물 → HCID 62139192, 화합물
반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:17]=[CH:18][CH:19]=1)[O:6][CH2:7][CH2:8][N:9]1[CH:13]=[C:12]([N+:14]([O-])=O)[CH:11]=[N:10]1>CCOC(C)=O.CCO.O=[Pt]=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:17]=[CH:18][CH:19]=1)[O:6][CH2:7][CH2:8][N:9]1[CH:13]=[C:12]([NH2:14])[CH:11]=[N:10]1참가 물질
5
실험 절차
To a solution of 1-(2-(3-methoxyphenoxy)ethyl)-4-nitro-1H-pyrazole (533 mg, 1.90 mmol), in EtOAc (2 mL, degassed) and EtOH (6 mL, degassed), PtO2 (42 mg, 0.19 mmol) was added and the reaction mixture was stirred at rt under a H2-atmosphere for 3 h. The mixture was diluted with EtOH, filtered over celite and the filter cake was rinsed with EtOH. The filtrate was concentrated to obtain the title compound as a pale brown oil. LC-MS conditions A: tR=0.53 min, [M+H]+=234.41.
후처리
- filtrationfiltered over celite
- washthe filter cake was rinsed with EtOH
- concentrationThe filtrate was concentrated
출처 및 근거
- ORD 기록
- ord-e3f3092420b84d9a9dd40a94e7a7b0a6
- 출처 데이터셋
- uspto-grants-2016_04
- 특허 번호
- US09303023B2
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