HCID 86704207, 화합물 → 1-[2-(4,6-Dimethoxy-pyrimidin-2-yloxy)-ethyl]-1H-pyrazol-4-ylamine

HRID 624013노트

반응식

HRID 624013 반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([O:11][CH2:12][CH2:13][N:14]2[CH:18]=[C:17]([N+:19]([O-])=O)[CH:16]=[N:15]2)[N:4]=1>CCOC(C)=O.CCO.O=[Pt]=O>[CH3:10][O:9][C:7]1[CH:8]=[C:3]([O:2][CH3:1])[N:4]=[C:5]([O:11][CH2:12][CH2:13][N:14]2[CH:18]=[C:17]([NH2:19])[CH:16]=[N:15]2)[N:6]=1

참가 물질

5

반응물 1

HCID 86704207HCID 86704207, 화합물

생성물 1

HCID 682827731-[2-(4,6-Dimethoxy-pyrimidin-2-yloxy)-ethyl]-1H-pyrazol-4-ylamine

시약·촉매·용매 3

HCID 345198Adams' catalyst촉매HCID 702Ethanol용매2회HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 4,6-dimethoxy-2-(2-(4-nitro-1H-pyrazol-1-yl)ethoxy)pyrimidine (2.05 g, 6.93 mmol), in EtOAc (3.0 mL, degassed) and EtOH (9 mL, degassed), PtO2 (135 mg, 0.70 mmol) was added and the reaction mixture was stirred at rt under a H2-atmosphere for 3 h. The mixture was diluted with EtOH, filtered over celite and the filter cake was rinsed with EtOH. The filtrate was concentrated to obtain the title compound as a red oil. LC-MS conditions A: tR=0.58 min, [M+H]+=266.02.

후처리

  1. filtrationfiltered over celite
  2. washthe filter cake was rinsed with EtOH
  3. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-1c04a8914b4b45e5958600a82c0491af
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09303023B2

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