1-(2-(4-nitro-1H-pyrazol-1-yl)ethyl)indoline → 1-(2-(Indolin-1-yl)ethyl)-1H-pyrazol-4-amine

HRID 624037노트

반응식

HRID 624037 반응식
[N+:1]([C:4]1[CH:5]=[N:6][N:7]([CH2:9][CH2:10][N:11]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:13][CH2:12]2)[CH:8]=1)([O-])=O>CCOC(C)=O.CCO.O=[Pt]=O>[N:11]1([CH2:10][CH2:9][N:7]2[CH:8]=[C:4]([NH2:1])[CH:5]=[N:6]2)[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:13][CH2:12]1

참가 물질

5

반응물 1

HCID 682835761-(2-(4-nitro-1H-pyrazol-1-yl)ethyl)indoline

생성물 1

HCID 621388071-(2-(Indolin-1-yl)ethyl)-1H-pyrazol-4-amine

시약·촉매·용매 3

HCID 345198Adams' catalyst촉매HCID 702Ethanol용매2회HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 1-(2-(4-nitro-1H-pyrazol-1-yl)ethyl)indoline (183 mg, 0.71 mmol) in EtOAc (0.7 mL, degassed) and EtOH (2 mL, degassed), PtO2 (14 mg, 0.07 mmol) was added and the reaction mixture was stirred at rt under a H2-atmosphere for 18 h. The mixture was diluted with EtOH, filtered over celite and the filter cake was rinsed with EtOH. The filtrate was concentrated to obtain the title compound as an oil, which was used in the next step without further purification. LC-MS conditions A: tR=0.51 min, [M+H]+=229.26.

후처리

  1. filtrationfiltered over celite
  2. washthe filter cake was rinsed with EtOH
  3. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-9580a8ee934d42178a693706bf38d015
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09303023B2

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