2-(4-Nitro-1H-pyrazol-1-yl)ethan-1-ol → 2-(4-Amino-1H-pyrazol-1-yl)ethanol

HRID 624062노트

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HRID 624062 반응식
[N+:1]([C:4]1[CH:5]=[N:6][N:7]([CH2:9][CH2:10][OH:11])[CH:8]=1)([O-])=O>CCOC(C)=O.CCO.O=[Pt]=O>[NH2:1][C:4]1[CH:5]=[N:6][N:7]([CH2:9][CH2:10][OH:11])[CH:8]=1

참가 물질

5

반응물 1

HCID 1620552-(4-Nitro-1H-pyrazol-1-yl)ethan-1-ol

생성물 1

HCID 284922672-(4-Amino-1H-pyrazol-1-yl)ethanol

시약·촉매·용매 3

HCID 345198Adams' catalyst촉매HCID 702Ethanol용매2회HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 2-(4-nitro-1H-pyrazol-1-yl)ethanol (9.12 g, 58.07 mmol) in EtOAc (20 mL, degassed) and EtOH (60 mL, degassed), PtO2 (1.13 g, 5.81 mmol) was added and the reaction mixture was stirred at rt under a H2-atmosphere for 18 h. The mixture was diluted with EtOH, filtered over celite and the filter cake was rinsed with EtOH. The filtrate was concentrated to obtain 2-(4-amino-1H-pyrazol-1-yl)ethanol as a red oil, which was used in the next step without further purification. LC-MS conditions A: tR=0.14 min, [M+H]+=128.24.

후처리

  1. filtrationfiltered over celite
  2. washthe filter cake was rinsed with EtOH
  3. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-5bcd7949ce0149e5889458edf52f2fa9
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09303023B2

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