2-(3,5-dimethyl-4-nitro-1H-pyrazol-1-yl)ethanol → HCID 28492268, 화합물
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[CH3:1][C:2]1[C:6]([N+:7]([O-])=O)=[C:5]([CH3:10])[N:4]([CH2:11][CH2:12][OH:13])[N:3]=1>CCOC(C)=O.CCO.O=[Pt]=O>[NH2:7][C:6]1[C:2]([CH3:1])=[N:3][N:4]([CH2:11][CH2:12][OH:13])[C:5]=1[CH3:10]참가 물질
5
실험 절차
To a solution of 2-(3,5-dimethyl-4-nitro-1H-pyrazol-1-yl)ethanol (624 mg, 3.37 mmol) in EtOAc (1.2 mL, degassed) and EtOH (3.6 mL, degassed), PtO2 (66 mg, 0.34 mmol) was added and the reaction mixture was stirred at rt under a H2-atmosphere for 30 h. The mixture was diluted with EtOH, filtered over celite and the filter cake was rinsed with EtOH. The filtrate was concentrated to obtain 2-(4-amino-3,5-dimethyl-1H-pyrazol-1-yl)ethanol as a pale brown solid, which was used in the next step without further purification. LC-MS conditions A: tR=0.16 min, [M+H]+=156.29.
후처리
- filtrationfiltered over celite
- washthe filter cake was rinsed with EtOH
- concentrationThe filtrate was concentrated
출처 및 근거
- ORD 기록
- ord-64b539c5722544fe886d95e3c08f3fba
- 출처 데이터셋
- uspto-grants-2016_04
- 특허 번호
- US09303023B2
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