Methanol → HCID 62230337, 화합물

HRID 624108노트

반응식

HRID 624108 반응식
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][N:2]1[C:10]([NH:12][C:13]1[CH:22]=[CH:21][C:16]([C:17]([O:19]C)=[O:18])=[CH:15][CH:14]=1)=[O:11].CO.[OH-].[Li+]>O1CCCC1>[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][N:2]1[C:10]([NH:12][C:13]1[CH:14]=[CH:15][C:16]([C:17]([OH:19])=[O:18])=[CH:21][CH:22]=1)=[O:11]

참가 물질

5

반응물 3

HCID 887MethanolHCID 3939Lithium HydroxideHCID 68748359HCID 68748359, 화합물

생성물 1

HCID 62230337HCID 62230337, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Methyl 4-(isoindoline-2-carboxamido)benzoate (1.65 g, 5.57 mmol) was dissolved in tetrahydrofuran (30 ml) and methanol (15.00 ml) followed by the addition of lithium hydroxide (11.14 ml, 22.27 mmol) and the mixture was allowed to stir at ambient temperature over the weekend. The organic solvent was removed under vacuum, the aqueous layer was adjusted to pH ˜3 with 2N aqueous HCl, and the resulting solid was filtered with water washes to provide the title compound after drying.

후처리

  1. customThe organic solvent was removed under vacuum
  2. filtrationthe resulting solid was filtered with water

출처 및 근거

ORD 기록
ord-8c7fe9ed83e84247b0878e79b93e256d
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09302989B2

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