Sodium Hydroxide → 5-Iodo-2-methoxy-4-methylbenzoic acid

HRID 624308노트

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HRID 624308 반응식
[I:1][C:2]1[C:3]([CH3:14])=[CH:4][C:5]([O:12][CH3:13])=[C:6]([CH:11]=1)[C:7]([O:9]C)=[O:8].[OH-].[Na+]>C(O)C>[I:1][C:2]1[C:3]([CH3:14])=[CH:4][C:5]([O:12][CH3:13])=[C:6]([CH:11]=1)[C:7]([OH:9])=[O:8]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 29934724Methyl 5-iodo-2-methoxy-4-methylbenzoate

생성물 1

HCID 468293605-Iodo-2-methoxy-4-methylbenzoic acid수율 76.9%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a mixture of methyl 5-iodo-2-methoxy-4-methylbenzoate (3.0 g, 9.80 mmol) in ethanol (10 ml) in a 50 ml RB flask was added an aqueous solution of NaOH (0.784 g, 19.60 mmol, 1M). The reaction mixture was stirred at room temperature overnight. The solvent was removed under vacuum, the solid filtered and dried to give the titled compound (2.2 g, 74%). LCMS: (ES+) m/z=292 (M+H)+; Column. PUROSPHER@star RP-18 (4×55) mm, 3 μm; Buffer: 20 mM NH4OAc IN WATER; Mphase A: Buffer+MeCN (90+10); Mphase B: Buffer+MeCN (10+90); Flow: 2.5 ml/min Time (min.): 0 2 2.5 3; % B: 0 100 100 0; RT: 1.04 min.

후처리

  1. customThe solvent was removed under vacuum
  2. filtrationthe solid filtered
  3. customdried

출처 및 근거

ORD 기록
ord-e27a0f9893b4462caed620253f2a30ad
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09303020B2

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