Hydrochloric Acid → 1-(Oxan-4-yl)piperidin-4-amine dihydrochloride

HRID 624345

반응식

HRID 624345 반응식
[O:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:12][CH2:11][CH:10]([NH:13]C(=O)OC(C)(C)C)[CH2:9][CH2:8]2)[CH2:3][CH2:2]1.[ClH:21]>ClCCl>[ClH:21].[ClH:21].[O:1]1[CH2:2][CH2:3][CH:4]([N:7]2[CH2:12][CH2:11][CH:10]([NH2:13])[CH2:9][CH2:8]2)[CH2:5][CH2:6]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 45792109tert-butyl N-[1-(oxan-4-yl)piperidin-4-yl]carbamate

생성물 1

HCID 451567511-(Oxan-4-yl)piperidin-4-amine dihydrochloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of EXAMPLE 49A (52.57 g) in dichloromethane (900 mL) was treated with 4M aqueous HCl (462 mL), mixed vigorously at room temperature for 16 hours and concentrated.

후처리

  1. additionmixed vigorously at room temperature for 16 hours
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-aa29623e44e643e9b3bda13b771f984c
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09303025B2

연결된 노트

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