1-Methyl-1,5,6,7-tetrahydro-4H-indazol-4-one → 1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-ol

HRID 62440

반응식

HRID 62440 반응식
[CH3:1][N:2]1[C:10]2[CH2:9][CH2:8][CH2:7][C:6](=[O:11])[C:5]=2[CH:4]=[N:3]1.[BH4-].[Na+]>CCO>[CH3:1][N:2]1[C:10]2[CH2:9][CH2:8][CH2:7][CH:6]([OH:11])[C:5]=2[CH:4]=[N:3]1

참가 물질

4

반응물 2

HCID 27657961-Methyl-1,5,6,7-tetrahydro-4H-indazol-4-oneHCID 4311764Sodium borohydride

생성물 1

HCID 138368981-methyl-4,5,6,7-tetrahydro-1H-indazol-4-ol수율 68.8%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 1-methyl-6,7-dihydro-1H-indazol-4(5H)-one (1 g, 6.7 mmol) in EtOH (20 mL) was added NaBH4 (1.2 g, 33.3 mmol) in portions. The resulting mixture was stirred at room temperature for 30 min. The solvent was removed under reduced pressure to afford the crude 1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-ol (700 mg, 68.8%), which was used in the next step directly. MS-ESI (m/z): 153 (M+1)+ (Acq Method: 10-80AB_2 min_220 &254.1 cm; Rt: 0.17 min)

후처리

  1. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-c9ed543f7ed5432c8ce38d7841ae8fe8
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09446130B2

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