Hydrochloric Acid → 1-(Oxan-4-yl)piperazine--hydrogen chloride (1/2)

HRID 624415노트

반응식

HRID 624415 반응식
[O:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]2)[CH2:3][CH2:2]1.[ClH:20]>CCOCC>[ClH:20].[ClH:20].[O:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 46785855HCID 46785855, 화합물

생성물 1

HCID 441204811-(Oxan-4-yl)piperazine--hydrogen chloride (1/2)

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To a solution of EXAMPLE 336A (3.92 g) in ether was added HCl (25 mL, 2M in ether) and the reaction mixture was stirred for 16 hours at room temperature. The solid product was filtered off, dried and used in next step without further purification.

후처리

  1. filtrationThe solid product was filtered off
  2. customdried
  3. customused in next step without further purification

출처 및 근거

ORD 기록
ord-138b7f02e2b34323a9cfec14d6691810
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09303025B2

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