(E)-Methyl 3-(2-amino-4-fluorophenyl)acrylate → 7-Fluoroquinolin-2(1H)-one
반응식
[NH2:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1/[CH:9]=[CH:10]/[C:11]([O:13]C)=O>C1COCC1.Cl>[F:8][C:6]1[CH:7]=[C:2]2[C:3]([CH:9]=[CH:10][C:11](=[O:13])[NH:1]2)=[CH:4][CH:5]=1참가 물질
4
반응 조건
- 온도
- 65 °C
실험 절차
A mixture of (E)-methyl 3-(2-amino-4-fluorophenyl)acrylate (30.38 g, 156 mmol) in THF (400 mL) and 3M hydrochloric acid (400 mL) was heated at 65° C. for 20 h. The mixture was cooled to RT and poured onto ice. The resulting precipitate was filtered, washed with copious amounts of water and dried in vacuo to give 20.65 g (81%) of a light-yellow amorphous solid. m/z=164 (M+1).
후처리
- temperatureThe mixture was cooled to RT
- additionpoured onto ice
- filtrationThe resulting precipitate was filtered
- washwashed with copious amounts of water
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-9ba7fd3c05aa4d91a64c2e198ff35b4b
- 출처 데이터셋
- uspto-grants-2016_04
- 특허 번호
- US09303028B2
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