Hydrochloric Acid → 5-Fluoro-1-(methylsulfonyl)-1H-indole-3-carboxylic acid

HRID 624662노트

반응식

HRID 624662 반응식
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:11]([CH3:14])(=[O:13])=[O:12])[CH:6]=[C:5]2[C:15]([O:17]C(C)(C)C)=[O:16].Cl>CCOC(C)=O>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:11]([CH3:14])(=[O:13])=[O:12])[CH:6]=[C:5]2[C:15]([OH:17])=[O:16]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 90031845tert-Butyl 5-fluoro-1-(methylsulfonyl)-1H-indole-3-carboxylate

생성물 1

HCID 900309845-Fluoro-1-(methylsulfonyl)-1H-indole-3-carboxylic acid

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A mixture of tert-butyl 5-fluoro-1-(methylsulfonyl)-1H-indole-3-carboxylate (150 mg, 0.479 mmol) and conc. HCl (0.2 ml, 2.394 mmol) in EtOAc (10 ml) was stirred at RT for 2 h. The mixture was then partially concentrated, and the resulting precipitate was collected by filtration, washed with EtOAc and dried in vacuo to afford the title compound as a white solid, which was used without further purification.

후처리

  1. concentrationThe mixture was then partially concentrated
  2. filtrationthe resulting precipitate was collected by filtration
  3. washwashed with EtOAc
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-0274125a8df04815ab79ff8755cea993
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09303045B2

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