Hydrochloric Acid → 1-(thiazol-2-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid

HRID 624669노트

반응식

HRID 624669 반응식
[OH-].[K+].[S:3]1[CH:7]=[CH:6][N:5]=[C:4]1[N:8]1[C:12]2=[N:13][CH:14]=[CH:15][CH:16]=[C:11]2[C:10]([C:17]([O:19]C)=[O:18])=[CH:9]1.Cl>CO.O>[S:3]1[CH:7]=[CH:6][N:5]=[C:4]1[N:8]1[C:12]2=[N:13][CH:14]=[CH:15][CH:16]=[C:11]2[C:10]([C:17]([OH:19])=[O:18])=[CH:9]1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 90030953methyl 1-(thiazol-2-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylate

생성물 1

HCID 900685261-(thiazol-2-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

Potassium hydroxide (38.5 mg, 0.687 mmol) was added to a solution of methyl 1-(thiazol-2-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylate (35.6 mg, 0.137 mmol) in MeOH (343 μl) and water (343 μl) at RT. The mixture was heated at 100° C. for 2 h. After cooling to RT, the mixture was acidified with 2 N HCl and then concentrated under reduced pressure. The crude mixture was used without further purification.

후처리

  1. temperatureAfter cooling to RT
  2. concentrationconcentrated under reduced pressure
  3. customThe crude mixture was used without further purification

출처 및 근거

ORD 기록
ord-0a8e767de5874d75a840f5d1131c7c8b
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09303045B2

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