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N-(tert-butoxycarbonyl)glycine → HCID 71668135, 화합물

HRID 624673
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HRID 624673 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([C:9]2[S:31][C:12]3=[N:13][C:14]([N:18]4[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]4)=[CH:15][C:16](=[O:17])[N:11]3[N:10]=2)[CH:5]=[C:6]([Br:8])[CH:7]=1.[NH:32](C(OC(C)(C)C)=O)[CH2:33][C:34](O)=[O:35].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C>CN(C=O)C.CCOC(C)=O>[NH2:32][CH2:33][C:34]([NH:1][C:2]1[CH:3]=[C:4]([C:9]2[S:31][C:12]3=[N:13][C:14]([N:18]4[CH2:19][CH2:20][NH:21][CH2:22][CH2:23]4)=[CH:15][C:16](=[O:17])[N:11]3[N:10]=2)[CH:5]=[C:6]([Br:8])[CH:7]=1)=[O:35]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 78288N-(tert-butoxycarbonyl)glycineHCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 89705355HCID 89705355, 화합물

생성물 1

HCID 71668135HCID 71668135, 화합물수율 120.5%

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of tert-butyl 4-(2-(3-amino-5-bromophenyl)-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)piperazine-1-carboxylate (30.0 mg, 0.059 mmol) in DMF (2 ml) are added Boc-Gly-OH (20.7 mg, 0.118 mmol), HATU (45.0 mg, 0.118 mmol) and i−Pr2NEt (31 μl, 0.177 mmol). The mixture is stirred at room temperature for 2 h. EtOAc (10 ml) is added and the solution is washed with H2O and brine. The organic layer is dried over Na2SO4. After removing EtOAc, the residue is purified by Biotage column chromatography (MeOH/DCM: 1/100 to 1/20 gradient) to give the desired product (33 mg, 84%).

후처리

  1. washthe solution is washed with H2O and brine
  2. dry with materialThe organic layer is dried over Na2SO4
  3. customAfter removing EtOAc
  4. customthe residue is purified by Biotage column chromatography (MeOH/DCM: 1/100 to 1/20 gradient)

출처 및 근거

ORD 기록
ord-4788668ce76445bfa89a7672eebbbcbf
출처 데이터셋
uspto-grants-2016_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09303044B2

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