Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → 5-Cyclopropyl-6-(2,2,2-trifluoro-1-methyl-ethoxy)-pyridine-2-carboxylic acid tert-butyl-methyl-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 2-Methyl-2-methylamino-1-propanol | HCID 422780 | — |
| 반응물 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 반응물 | 5-Cyclopropyl-6-(1,1,1-trifluoropropan-2-yloxy)picolinic acid | HCID 71087435 | — |
| 생성물 | 5-Cyclopropyl-6-(2,2,2-trifluoro-1-methyl-ethoxy)-pyridine-2-carboxylic acid tert-butyl-methyl-amide | HCID 90203497 | — |
반응 단계
In analogy to the procedure described in Example 47 b), 5-cyclopropyl-6-(1,1,1-trifluoropropan-2-yloxy)picolinic acid was reacted with 2-methyl-2-(methylamino)propan-1-ol (CAN 27646-80-6) in the presence of TBTU and DIEA to obtain the title compound as white solid; MS (EI): m/e=345.4 [MH+].
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09303012B2 |
| 출처 데이터셋 | uspto-grants-2016_04 |
| ORD ID | ord-ca2b144c4292424ba088e09d26b67367 |
| 출처 메모 | uspto-grants-2016_04 |