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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 624884생성일: 2026년 10월 27일

4,4-Dimethyl oxazolidine → [5-Cyclopropyl-6-(2-methyl-propane-1-sulfonyl)-pyridin-2-yl]-(4,4-dimethyl-oxazolidin-3-yl)-methanone

https://huagongshe.com/reaction/624884

반응식

참여 물질

역할이름HCID투입량
반응물4,4-Dimethyl oxazolidineHCID 62010—
반응물DiisopropylethylamineHCID 81531—
반응물O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 2733207—
반응물5-Cyclopropyl-6-(isobutylsulfonyl)picolinic acidHCID 71087731—
생성물[5-Cyclopropyl-6-(2-methyl-propane-1-sulfonyl)-pyridin-2-yl]-(4,4-dimethyl-oxazolidin-3-yl)-methanoneHCID 76282133—

반응 단계

In analogy to the procedure described in Example 47 b), 5-cyclopropyl-6-(isobutylsulfonyl)picolinic acid (Example 6 d)) was reacted with 4,4-dimethyloxazolidine (CAN 51200-87-4) in the presence of TBTU and DIEA to obtain the title compound as colorless solid; MS (EI): m/e=367.4 [MH+].

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09303012B2
출처 데이터셋uspto-grants-2016_04
ORD IDord-96d7cf8d184b41c88d30053ce9107082
출처 메모uspto-grants-2016_04