Diisopropylethylamine → HCID 76282617, 화합물

HRID 624944노트

반응식

HRID 624944 반응식
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[N:15]2[CH2:18][C:17]([F:20])([F:19])[CH2:16]2)[CH2:3][CH2:2]1.Cl.[O:22]1[C:26]2([CH2:30][CH2:29][NH:28][CH2:27]2)[CH2:25][CH:24]([OH:31])[CH2:23]1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.CCN(C(C)C)C(C)C>>[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([N:28]3[CH2:29][CH2:30][C:26]4([O:22][CH2:23][CH:24]([OH:31])[CH2:25]4)[CH2:27]3)=[O:14])[CH:9]=[CH:8][C:7]=2[N:15]2[CH2:18][C:17]([F:20])([F:19])[CH2:16]2)[CH2:2][CH2:3]1

참가 물질

5

반응물 4

HCID 81531DiisopropylethylamineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 710872926-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acidHCID 90204446HCID 90204446, 화합물

생성물 1

HCID 76282617HCID 76282617, 화합물

실험 절차

In analogy to the procedure described in Example 47 b), 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b)) was reacted with 1-oxa-7-azaspiro[4.4]nonan-3-ol hydrochloride in the presence of TBTU and DIEA to obtain the title compound as yellow oil; MS (EI): m/e=410.5 [MH+].

출처 및 근거

ORD 기록
ord-3879cbbc41fa4ee69699e4e76e1ab4a3
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09303012B2

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