HCID 86711148, 화합물 → tert-Butyl 3-(aminomethyl)-4-(2-(2-hydroxyethoxy)ethyl)piperazine-1-carboxylate

HRID 625171노트

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HRID 625171 반응식
[C:1]([CH:3]1[N:8]([CH2:9][CH2:10][O:11][CH2:12][CH2:13][OH:14])[CH2:7][CH2:6][N:5]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:4]1)#[N:2]>CO.[Ni]>[NH2:2][CH2:1][CH:3]1[N:8]([CH2:9][CH2:10][O:11][CH2:12][CH2:13][OH:14])[CH2:7][CH2:6][N:5]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:4]1

참가 물질

4

반응물 1

HCID 86711148HCID 86711148, 화합물

생성물 1

HCID 86711149tert-Butyl 3-(aminomethyl)-4-(2-(2-hydroxyethoxy)ethyl)piperazine-1-carboxylate

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

To a solution of tert-butyl 3-cyano-4-(2-(2-hydroxyethoxy)ethyl)piperazine-1-carboxylate, prepared as described in the previous step, (9.9 g, 33.1 mmol) in methanol (20 mL) was added Raney Ni (15 g). The reaction solution was stirred at room temperature overnight under hydrogen atmosphere (50 psi). The mixture was filtered and concentrated to provide the product, which was used in the next step without additional purification.

후처리

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated
  3. customto provide the product, which
  4. customwas used in the next step without additional purification

출처 및 근거

ORD 기록
ord-2dd9145331b94ac994de69388b47a037
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09304126B2

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