Methyl(2-(morpholin-4-yl)ethyl)amine → N1-methyl-N1-(2-morpholinoethyl)-N3-(4-(piperidin-1-yl)-2-(4-((3-(trifluoromethyl)benzyl)carbamoyl)pyridin-2-yl)phenyl)isophthalamide

HRID 625254

반응식

HRID 625254 반응식
CNCCN1CCOCC1.FC(F)(F)C1C=C(C=CC=1)CNC(C1C=CN=C(C2C=C(N3CCCCC3)C=CC=2NC(C2C=C(C=CC=2)C(O)=O)=O)C=1)=O.[CH2:55]([N:57]([CH2:101][CH2:102][N:103]1[CH2:108][CH2:107][O:106][CH2:105][CH2:104]1)[C:58](=[O:100])[C:59]1[CH:99]=[CH:98][CH:97]=[C:61]([C:62]([NH:64][C:65]2[CH:70]=[CH:69][C:68]([N:71]3[CH2:76][CH2:75][CH2:74][CH2:73][CH2:72]3)=[CH:67][C:66]=2[C:77]2[CH:82]=[C:81]([C:83](=[O:96])[NH:84][CH2:85][C:86]3[CH:91]=[CH:90][CH:89]=[C:88]([C:92]([F:95])([F:94])[F:93])[CH:87]=3)[CH:80]=[CH:79][N:78]=2)=[O:63])[CH:60]=1)C>>[CH3:55][N:57]([CH2:101][CH2:102][N:103]1[CH2:108][CH2:107][O:106][CH2:105][CH2:104]1)[C:58](=[O:100])[C:59]1[CH:99]=[CH:98][CH:97]=[C:61]([C:62]([NH:64][C:65]2[CH:70]=[CH:69][C:68]([N:71]3[CH2:76][CH2:75][CH2:74][CH2:73][CH2:72]3)=[CH:67][C:66]=2[C:77]2[CH:82]=[C:81]([C:83](=[O:96])[NH:84][CH2:85][C:86]3[CH:91]=[CH:90][CH:89]=[C:88]([C:92]([F:94])([F:95])[F:93])[CH:87]=3)[CH:80]=[CH:79][N:78]=2)=[O:63])[CH:60]=1

참가 물질

4

반응물 3

HCID 14979282Methyl(2-(morpholin-4-yl)ethyl)amineHCID 665867843-((2-(4-((3-(Trifluoromethyl)benzyl)carbamoyl)pyridin-2-yl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzoic acidHCID 69631832N1-Ethyl-N1-(2-morpholinoethyl)-N3-(4-(piperidin-1-yl)-2-(4-((3-(trifluoromethyl)benzyl)carbamoyl)pyridin-2-yl)phenyl)isophthalamide

생성물 1

HCID 69631879N1-methyl-N1-(2-morpholinoethyl)-N3-(4-(piperidin-1-yl)-2-(4-((3-(trifluoromethyl)benzyl)carbamoyl)pyridin-2-yl)phenyl)isophthalamide

실험 절차

This compound was prepared by coupling N-methyl-2-morpholinoethylamine to 3-((4-(piperidin-1-yl)-2-(4-((3-(trifluoromethyl)benzyl)carbamoyl)pyridin-2-yl)phenyl)-carbamoyl)benzoic acid 4.1e, using the procedure described for the preparation of N1-ethyl-N1-(2-morpholinoethyl)-N3-(4-(piperidin-1-yl)-2-(4-((3-(trifluoromethyl)benzyl)-carbamoyl)pyridin-2-yl)phenyl)isophthalamide 4.8. MS (ES, m/z): 743 [M+H]+

후처리

  1. customThis compound was prepared

출처 및 근거

ORD 기록
ord-7a3a0aa7a25e4b8e9612b5a7e056fcf8
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09301951B2

연결된 노트

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