Water → HCID 84045984, 화합물

HRID 625697노트

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HRID 625697 반응식
[Br:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[CH:4][C:3]=1[CH2:10][CH2:11][C:12]([O:14]C)=[O:13].O>[OH-].[Na+].CC(O)C>[Br:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[CH:4][C:3]=1[CH2:10][CH2:11][C:12]([OH:14])=[O:13]

참가 물질

5

반응물 2

HCID 962WaterHCID 89826041Methyl 3-(2-bromo-3,5-difluorophenyl)propanoate

생성물 1

HCID 84045984HCID 84045984, 화합물

시약·촉매·용매 2

HCID 3776Isopropanol용매HCID 14798Sodium Hydroxide용매

실험 절차

Methyl 3-(2-bromo-3,5-difluorophenyl)propanoate (prepared as described in Step 1, 4.3 g) in aqueous NaOH (4 M, 13.5 mL) and 2-propanol (30 mL) is heated at 50° C. for 2 hours. Water is added, the mixture washed with diethyl ether, acidified to ca. pH 5 by adding concentrated aqueous HCl, and extracted twice with diethyl ether. The combined extracts of the acidified mixture are washed with brine and volatiles evaporated under reduced pressure. The resulting material (Yield 3.6 g) is used in the next step without further purification. LC (METHOD 7): tR=0.99 min.

후처리

  1. washthe mixture washed with diethyl ether
  2. additionby adding concentrated aqueous HCl
  3. extractionextracted twice with diethyl ether
  4. washThe combined extracts of the acidified mixture are washed with brine and volatiles
  5. customevaporated under reduced pressure
  6. customThe resulting material (Yield 3.6 g) is used in the next step without further purification

출처 및 근거

ORD 기록
ord-c0c3a2f4b8794fad9273437e85495432
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09308194B2

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