Water → HCID 86732632, 화합물

HRID 626393노트

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HRID 626393 반응식
CC1C=CC(S(O[CH2:12][CH2:13][C@H:14]2[CH2:17][CH2:16][O:15]2)(=O)=O)=CC=1.[N-:18]=[N+:19]=[N-:20].[Na+].O>CS(C)=O>[N:18]([CH2:12][CH2:13][C@H:14]1[CH2:17][CH2:16][O:15]1)=[N+:19]=[N-:20]

참가 물질

5

반응물 3

HCID 962WaterHCID 33557Sodium AzideHCID 86732633HCID 86732633, 화합물

생성물 1

HCID 86732632HCID 86732632, 화합물

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

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온도
55 °C

실험 절차

The mixture of (R)-2-(oxetan-2-yl)ethyl 4-methylbenzenesulfonate (80 mg, 0.31 mmol), NaN3 (30 m2, 0.465 mmol) and KI (5 mg) in DMSO (1 mL) was heated to 55° C. and stirred for 18 h. Then the mixture was cooled to RT, then it was poured into 20 mL of water, then extracted with MTBE (20 mL×3), the organic layers was washed with 1-120 (10 mL), brine (10 mL), and dried over Na2SO4. After filtration, the filtrate was concentrated under the reduced pressure. to give the titled compound which was used to the next step without further purification.

후처리

  1. temperatureThen the mixture was cooled to RT
  2. extractionextracted with MTBE (20 mL×3)
  3. washthe organic layers was washed with 1-120 (10 mL), brine (10 mL)
  4. dry with materialdried over Na2SO4
  5. filtrationAfter filtration
  6. concentrationthe filtrate was concentrated under the reduced pressure

출처 및 근거

ORD 기록
ord-3cd014bad5fc4d2fa9dc946c3275d6de
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09309227B2

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