2-Methylcyclohexanone → HCID 178424364, 화합물

HRID 62658

반응식

HRID 62658 반응식
[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C:3]1=O.[C:9]1([C@H:15]([NH2:17])[CH3:16])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>C1(C)C=CC=CC=1>[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4]/[C:3]/1=[N:17]\[C@@H:15]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH3:16]

참가 물질

4

반응물 2

HCID 114192-MethylcyclohexanoneHCID 6431891-Phenethylamine, (+)-

생성물 1

HCID 178424364HCID 178424364, 화합물수율 84%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A stirred solution of 2-methylcyclohexanone (5 g, 44.64 mmol) and (R)-1-phenylethanamine (5.4 g, 44.64 mmol) in toluene (50 mL) was maintained at 140-145° C. for 24 h. The solvent was removed under reduced pressure to afford 8 g (84%) of a diastereomeric mixture of (1R,E)-N-(2-methylcyclohexylidene)-1-phenylethanamine (I-8a) as a pale yellow oil.

후처리

  1. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-a6494b17610041718444964d445c6e04
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447039B2

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