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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Hydrochloric Acid → 1-((1-Methoxy-4-methyl-1-oxopentan-2-yl)amino)-1-oxopent-4-yn-2-aminium chloride

HRID 627577
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인쇄 미리보기

반응식

HRID 627577 반응식
C(OC([NH:8][CH:9]([CH2:22][C:23]#[CH:24])[C:10]([NH:12][CH:13]([CH2:18][CH:19]([CH3:21])[CH3:20])[C:14]([O:16][CH3:17])=[O:15])=[O:11])=O)(C)(C)C.[ClH:25].O1CCOCC1>C(Cl)Cl>[Cl-:25].[CH3:17][O:16][C:14](=[O:15])[CH:13]([NH:12][C:10](=[O:11])[CH:9]([NH3+:8])[CH2:22][C:23]#[CH:24])[CH2:18][CH:19]([CH3:21])[CH3:20]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 90010236Methyl 2-(2-((tert-butoxycarbonyl)amino)pent-4-ynamido)-4-methylpentanoate

생성물 1

HCID 900103681-((1-Methoxy-4-methyl-1-oxopentan-2-yl)amino)-1-oxopent-4-yn-2-aminium chloride수율 96%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트

A solution of compound 1 (10.55 g: 31 mmol) in DCM (100 mL) was treated with 4M HCl in dioxane (78 mL; 0.31 mol) and stirred at room temperature for 3 h while monitoring the disappearance of the starting material by TLC. The solvent was removed on the rotary evaporator and the residue was treated with ether and then concentrated to give 2 as an off white solid (8.3 g; 96% yield).

후처리

  1. customThe solvent was removed on the rotary evaporator
  2. additionthe residue was treated with ether
  3. concentrationconcentrated
  4. customto give 2 as an off white solid (8.3 g; 96% yield)

출처 및 근거

ORD 기록
ord-1254d62114c142c2a9d0b8dbb023b667
출처 데이터셋
uspto-grants-2016_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09309284B2

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