Methyl 5-(2,2-difluoroethoxy)-3-methylpyrazine-2-carboxylate → 5-(2,2-Difluoroethoxy)-3-methylpyrazine-2-carboxylic acid

HRID 627705노트

반응식

HRID 627705 반응식
[F:1][CH:2]([F:16])[CH2:3][O:4][C:5]1[N:6]=[C:7]([CH3:15])[C:8]([C:11]([O:13]C)=[O:12])=[N:9][CH:10]=1>Cl.O1CCOCC1>[F:16][CH:2]([F:1])[CH2:3][O:4][C:5]1[N:6]=[C:7]([CH3:15])[C:8]([C:11]([OH:13])=[O:12])=[N:9][CH:10]=1

참가 물질

4

반응물 1

HCID 86728150Methyl 5-(2,2-difluoroethoxy)-3-methylpyrazine-2-carboxylate

생성물 1

HCID 867281515-(2,2-Difluoroethoxy)-3-methylpyrazine-2-carboxylic acid수율 100%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 312751,4-Dioxane용매

실험 절차

A mixture of methyl 5-(2,2-difluoroethoxy)-3-methylpyrazine-2-carboxylate (63.8 mg, 0.275 mmol) in aqueous 2N HCl (1 mL) and Dioxane (2 mL) was stirred at ambient temperature for 20 hrs. The reaction was concentrated and the resulting solid was rinsed with acetonitrile. The filtrate was collected and concentrated in vacuo to give the title compound (60 mg, 0.275 mmol, 100%) as a white solid. MS m/z=219.1 (M+H).

후처리

  1. concentrationThe reaction was concentrated
  2. washthe resulting solid was rinsed with acetonitrile
  3. customThe filtrate was collected
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-adc4f4ef645c432a88f34d06c3fca6ee
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09309263B2

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