Dicyclohexylcarbodiimide → 2-(2-Dodecanoylamino-3-hydroxybutanoylamino)-3-hydroxybutanoic acid
반응식
[C:1]([NH:14][CH:15]([CH:19]([OH:21])[CH3:20])[C:16]([OH:18])=O)(=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].C[O:23][C:24](=[O:30])[CH:25]([NH2:29])[CH:26]([OH:28])[CH3:27].C1(N=C=NC2CCCCC2)CCCCC1.[OH-].[Na+]>>[C:1]([NH:14][CH:15]([CH:19]([OH:21])[CH3:20])[C:16]([NH:29][CH:25]([CH:26]([OH:28])[CH3:27])[C:24]([OH:30])=[O:23])=[O:18])(=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]참가 물질
5
실험 절차
2-Dodecanoylamino-3-hydroxybutanoic acid (15.07 g) and 2-amino-3-hydroxybutanoic acid methyl ester (6.66 g) were condensed with dicyclohexylcarbodiimide (10.31 g). Thereafter, methyl ester was hydrolyzed with sodium hydroxide to give 2-(2-dodecanoylamino-3-hydroxybutanoylamino)-3-hydroxybutanoic acid (10.24 g). The structure thereof was identified by 1H-NMR (400 MHz, CD3OD, r.t.).