Dimethylformamide dimethyl acetal → HCID 178484333, 화합물

HRID 628079노트

반응식

HRID 628079 반응식
[F:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[CH3:12][N:13]([CH:15](OC)OC)[CH3:14]>>[CH3:12][N:13]([CH3:15])/[CH:14]=[N:6]/[C:4](=[O:5])[C:3]1[CH:7]=[CH:8][C:9]([F:11])=[CH:10][C:2]=1[F:1]

참가 물질

3

반응물 2

HCID 78373Dimethylformamide dimethyl acetalHCID 1235882,4-Difluorobenzamide

생성물 1

HCID 178484333HCID 178484333, 화합물수율 91%

반응 조건

온도
120 °C

실험 절차

A suspension of 2,4-difluorobenzamide (5 g, 32 mmol) in DMF-DMA (10 mL) was heated at 120° C. for 2.5 h, allowed to cool down to RT and filtered to afford the title compound as a white solid (6.16 g, 91%). 1H NMR (CDCl3): 8.60 (1H, s), 8.19-8.12 (1H, m), 6.91-6.79 (2H, m), 3.19 (6H, m).

후처리

  1. temperatureto cool down to RT
  2. filtrationfiltered

출처 및 근거

ORD 기록
ord-9b1d9da7822445b3822860df8415e4c5
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09309265B2

반응 노트

불러오는 중…