Fenipentol → (1-Bromopentyl)benzene

HRID 628264노트

반응식

HRID 628264 반응식
P(Br)(Br)[Br:2].[C:5]1([CH:11](O)[CH2:12][CH2:13][CH2:14][CH3:15])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>CCOCC>[Br:2][CH:11]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH2:12][CH2:13][CH2:14][CH3:15]

참가 물질

4

반응물 2

HCID 3338FenipentolHCID 24614Phosphorus tribromide

생성물 1

HCID 10900349(1-Bromopentyl)benzene

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

PBr3 (0.171 mL, 1.82 mmol, Aldrich) was added to a solution of 1-phenylpentan-1-ol (0.500 g, 3.04 mmol, Alfa Aesar) in Et2O (3.2 mL) at 0° C. The reaction was allowed to reach ambient temperature and then was quenched with ice water and diluted with hexanes. The layers were separated and the organic layer was washed with water and then with brine, dried over sodium sulfate, filtered and concentrated. Flash chromatography, eluting with hexanes afforded product (0.15 g, 22%).

후처리

  1. customto reach ambient temperature
  2. customwas quenched with ice water
  3. additiondiluted with hexanes
  4. customThe layers were separated
  5. washthe organic layer was washed with water
  6. dry with materialwith brine, dried over sodium sulfate
  7. filtrationfiltered
  8. concentrationconcentrated
  9. washFlash chromatography, eluting with hexanes afforded product (0.15 g, 22%)

출처 및 근거

ORD 기록
ord-48cca4ff248444dc9b37fc291373a27a
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09309246B2

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