(E)-3-(4-benzyloxy-3,5-difluoro-phenyl)-acrylic acid ethyl ester → Ethyl 3-(3,5-difluoro-4-hydroxyphenyl)propanoate

HRID 62836

반응식

HRID 62836 반응식
[CH2:1]([O:3][C:4](=[O:23])/[CH:5]=[CH:6]/[C:7]1[CH:12]=[C:11]([F:13])[C:10]([O:14]CC2C=CC=CC=2)=[C:9]([F:22])[CH:8]=1)[CH3:2]>CCO.[Pd]>[CH2:1]([O:3][C:4](=[O:23])[CH2:5][CH2:6][C:7]1[CH:12]=[C:11]([F:13])[C:10]([OH:14])=[C:9]([F:22])[CH:8]=1)[CH3:2]

참가 물질

4

반응물 1

HCID 90118234(E)-3-(4-benzyloxy-3,5-difluoro-phenyl)-acrylic acid ethyl ester

생성물 1

HCID 23136305Ethyl 3-(3,5-difluoro-4-hydroxyphenyl)propanoate수율 98%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

(E)-3-(4-Benzyloxy-3,5-difluoro-phenyl)-acrylic acid ethyl ester (1.2 g, 3.77 mmol) obtained in Step C was dissolved in EtOH (20 mL), and 10% Pd/C (120 mg) was added to the solution. The mixture was stirred at room temperature under hydrogen atmosphere for 12 hours. The reactant was filtered by using celite and concentrated under reduced pressure to obtain the title compound (0.85 g, 98%).

후처리

  1. filtrationThe reactant was filtered
  2. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-04b6b1677efc443d9d11e4b92fcd26ee
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447044B2

연결된 노트

불러오는 중…