3-(4-Hydroxyphenyl)propionic acid → Benzenepropanoic acid, 4-hydroxy-, methyl ester

HRID 62838

반응식

HRID 62838 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([OH:12])=[O:11])=[CH:4][CH:3]=1.Cl.O1CCOC[CH2:15]1>CO>[CH3:15][O:11][C:10](=[O:12])[CH2:9][CH2:8][C:5]1[CH:4]=[CH:3][C:2]([OH:1])=[CH:7][CH:6]=1

참가 물질

4

반응물 2

HCID 103943-(4-Hydroxyphenyl)propionic acidHCID 204431481,4-Dioxane hydrochloride

생성물 1

HCID 79706Benzenepropanoic acid, 4-hydroxy-, methyl ester수율 100.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

After 3-(4-hydroxy-phenyl)propionic acid (3 g, 18 mmol) was added with MeOH (6 mL), 4M HCl/dioxane solution (18 mL, 72 mmol) was added thereto, and the mixture was stirred at room temperature for 3 hours. The reactant was concentrated, added with EtOAc, and then washed with NaCl aqueous solution. The organic layer was separated, dried with MgSO4, and filtered to obtain the title compound (3.26 g, 99%).

후처리

  1. additionwas added
  2. concentrationThe reactant was concentrated
  3. additionadded with EtOAc
  4. washwashed with NaCl aqueous solution
  5. customThe organic layer was separated
  6. dry with materialdried with MgSO4
  7. filtrationfiltered

출처 및 근거

ORD 기록
ord-ec3f833bd73143d4a3ef43c7709226b4
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447044B2

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