3-(4-Hydroxyphenyl)propionic acid → Benzenepropanoic acid, 4-hydroxy-, methyl ester
반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([OH:12])=[O:11])=[CH:4][CH:3]=1.Cl.O1CCOC[CH2:15]1>CO>[CH3:15][O:11][C:10](=[O:12])[CH2:9][CH2:8][C:5]1[CH:4]=[CH:3][C:2]([OH:1])=[CH:7][CH:6]=1참가 물질
4
실험 절차
After 3-(4-hydroxy-phenyl)propionic acid (3 g, 18 mmol) was added with MeOH (6 mL), 4M HCl/dioxane solution (18 mL, 72 mmol) was added thereto, and the mixture was stirred at room temperature for 3 hours. The reactant was concentrated, added with EtOAc, and then washed with NaCl aqueous solution. The organic layer was separated, dried with MgSO4, and filtered to obtain the title compound (3.26 g, 99%).
후처리
- additionwas added
- concentrationThe reactant was concentrated
- additionadded with EtOAc
- washwashed with NaCl aqueous solution
- customThe organic layer was separated
- dry with materialdried with MgSO4
- filtrationfiltered
출처 및 근거
- ORD 기록
- ord-ec3f833bd73143d4a3ef43c7709226b4
- 출처 데이터셋
- uspto-grants-2016_09
- 특허 번호
- US09447044B2
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