Triphosgene → 1-Bromo-3-isocyanato-2-methyl-benzene

HRID 628499노트

반응식

HRID 628499 반응식
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH2:8])[C:3]=1[CH3:9].Cl[C:11](Cl)([O:13]C(=O)OC(Cl)(Cl)Cl)Cl>C1(C)C=CC=CC=1>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N:8]=[C:11]=[O:13])[C:3]=1[CH3:9]

참가 물질

4

반응물 2

HCID 94429TriphosgeneHCID 1235383-Bromo-o-toluidine

생성물 1

HCID 655423311-Bromo-3-isocyanato-2-methyl-benzene수율 106.3%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of 1-bromo-2-methyl-3-aminobenzene 25.0 g, triphosgene 60.0 g and toluene 400 ml was stirred with heating under reflux for three hours. The reaction mixture after standing to cool was concentrated under reduced pressure to give 1-bromo-3-isocyanato-2-methylbenzene 30.3 g.

후처리

  1. temperaturewith heating
  2. temperatureunder reflux for three hours
  3. temperatureto cool
  4. concentrationwas concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-5f6203d8a4e94671af14d4942d38cdf1
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09314023B2

반응 노트

불러오는 중…