Methanol → 2-Chloro-6-methoxypyridine-3-carboxylic acid
반응식
[K].[Cl:2][C:3]1[N:11]=[C:10](Cl)[CH:9]=[CH:8][C:4]=1[C:5]([OH:7])=[O:6].[CH3:13][OH:14]>>[Cl:2][C:3]1[N:11]=[C:10]([O:14][CH3:13])[CH:9]=[CH:8][C:4]=1[C:5]([OH:7])=[O:6]참가 물질
4
실험 절차
Potassium botoxide (483 mg, 4.31 mmol) and MeOH (8 mL) were added to 2,6-dichloro-nicotinic acid (207 mg, 1.07 mmol), and the mixture was stirred using microwave at 60° C. for 1 hour. After the termination of the reaction, the reactant was filtered, and 1N HCl was added thereto at 0° C. to adjust the pH to 3. The solid was dried by N2 gas to obtain the title compound (106 mg, 52%).
후처리
- customat 60° C.
- customfor 1 hour
- customAfter the termination of the reaction
- filtrationthe reactant was filtered
- addition1N HCl was added
- customat 0° C.
- dry with materialThe solid was dried by N2 gas
출처 및 근거
- ORD 기록
- ord-8d8eac4a91ad46bab51f5aec9a772f99
- 출처 데이터셋
- uspto-grants-2016_09
- 특허 번호
- US09447044B2
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