Sulfuric Acid → HCID 90118322, 화합물

HRID 62895노트

반응식

HRID 62895 반응식
Cl[CH2:2][C:3]1[C:12]2[C:7](=[C:8]([F:15])[C:9]([OH:14])=[C:10]([F:13])[CH:11]=2)[O:6][C:5](=[O:16])[CH:4]=1.S(=O)(=O)(O)[OH:18]>[OH-].[Na+]>[F:13][C:10]1[C:9]([OH:14])=[C:8]([F:15])[C:7]2[O:6][CH:2]=[C:3]([CH2:4][C:5]([OH:16])=[O:18])[C:12]=2[CH:11]=1

참가 물질

4

반응물 2

HCID 1118Sulfuric AcidHCID 18757590HCID 18757590, 화합물

생성물 1

HCID 90118322HCID 90118322, 화합물

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

4-Chloromethyl-6,8-difluoro-7-hydroxy-2-chromenone (0.2 g, 0.81 mmol) obtained in Step A was dissolved in 1N NaOH aqueous solution (8 mL), and the mixture was stirred under reflux for 2 hours. The reactant was acidified by the addition of sulfuric acid, and then extracted with EtOAc. The organic layer was dried with MgSO4, and distilled under reduced pressure to obtain the title compound (0.16 g).

후처리

  1. temperatureunder reflux for 2 hours
  2. extractionextracted with EtOAc
  3. dry with materialThe organic layer was dried with MgSO4
  4. distillationdistilled under reduced pressure

출처 및 근거

ORD 기록
ord-fa832b321433472cad9a2755ba052a0b
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447044B2

반응 노트

불러오는 중…