Hydrazine Sulfate → HCID 88768920, 화합물

HRID 629201노트

반응식

HRID 629201 반응식
[Cl:1][C:2]1[C:7]2[C:8](=O)[O:9][CH:10](O)[C:6]=2[CH:5]=[C:4]([Cl:13])[N:3]=1.S(O)(O)(=O)=O.[NH2:19][NH2:20].C([O-])(=O)C.[Na+]>O>[Cl:1][C:2]1[C:7]2[C:8](=[O:9])[NH:19][N:20]=[CH:10][C:6]=2[CH:5]=[C:4]([Cl:13])[N:3]=1

참가 물질

5

반응물 3

HCID 24842Hydrazine SulfateHCID 517045Sodium AcetateHCID 89972412HCID 89972412, 화합물

생성물 1

HCID 88768920HCID 88768920, 화합물

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

To a suspension of 4,6-dichloro-1-hydroxy-1H-furo[3,4-c]pyridin-3-one (9.37 g) stirring in water (100 ml) was added hydrazine sulfate (10.58 ml) and sodium acetate (13.56 g). The reaction mixture was heated at reflux and stirred for 2 h. The reaction mixture was cooled to RT, diluted with water (150 ml) and extracted with EtOAc (2×75 ml). The combined organic layers were washed with saturated Na2CO3 solution and dried over Na2SO4. Evaporation to dryness gave the desired product as brown solid.

후처리

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux
  3. extractionextracted with EtOAc (2×75 ml)
  4. washThe combined organic layers were washed with saturated Na2CO3 solution
  5. dry with materialdried over Na2SO4
  6. customEvaporation to dryness

출처 및 근거

ORD 기록
ord-8c9942035d80453ba2ad8fdc7f24cb17
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09315500B2

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