Water → Methyl 5-bromo-3-chloro-2-hydroxy-4-(trifluoromethyl)benzoate

HRID 629357노트

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HRID 629357 반응식
[Cl:1][C:2]1[C:3]([OH:16])=[C:4]([CH:9]=[CH:10][C:11]=1[C:12]([F:15])([F:14])[F:13])[C:5]([O:7][CH3:8])=[O:6].[Br:17]N1C(=O)CCC1=O.O>CN(C=O)C>[Br:17][C:10]1[C:11]([C:12]([F:14])([F:15])[F:13])=[C:2]([Cl:1])[C:3]([OH:16])=[C:4]([CH:9]=1)[C:5]([O:7][CH3:8])=[O:6]

참가 물질

5

반응물 3

HCID 962WaterHCID 67184N-bromobutanimideHCID 118468129Methyl 3-chloro-2-hydroxy-4-(trifluoromethyl)benzoate

생성물 1

HCID 118468280Methyl 5-bromo-3-chloro-2-hydroxy-4-(trifluoromethyl)benzoate수율 84.8%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
15 °C

실험 절차

To a solution of methyl 3-chloro-2-hydroxy-4-(trifluoromethyl)benzoate (6.30 g) in DMF (65.0 mL) was added N-bromosuccinimide (4.41 g), and the mixture was stirred at 15° C. for 16 hr. The reaction mixture was poured into water, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (7.00 g).

후처리

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe organic layer was washed with saturated brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-e3f3c47a277c43b4bc0cbd5465f0b5c0
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09315458B2

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