N-bromobutanimide → 5-Bromo-3-fluoro-2-hydroxy-4-methoxybenzoic acid

HRID 629479노트

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HRID 629479 반응식
[F:1][C:2]1[C:3]([OH:13])=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[C:5]([OH:7])=[O:6].C1C(=O)N([Br:21])C(=O)C1>CN(C=O)C>[Br:21][C:9]1[C:10]([O:11][CH3:12])=[C:2]([F:1])[C:3]([OH:13])=[C:4]([CH:8]=1)[C:5]([OH:7])=[O:6]

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 847699353-Fluoro-2-hydroxy-4-methoxybenzoic acid

생성물 1

HCID 848075045-Bromo-3-fluoro-2-hydroxy-4-methoxybenzoic acid

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
25 °C

실험 절차

To a solution of 3-fluoro-2-hydroxy-4-methoxybenzoic acid (7.30 g) in DMF (70.0 mL) was added NBS, and the mixture was stirred at 25° C. for 2 hr. The solvent was evaporated under reduced pressure, and the residue was diluted with ethyl acetate. The mixture was washed with water and saturated brine, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (8.86 g).

후처리

  1. customThe solvent was evaporated under reduced pressure
  2. additionthe residue was diluted with ethyl acetate
  3. washThe mixture was washed with water and saturated brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-5d0f347f800e4cba9730170a4ddecd97
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09315458B2

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