Hydrochloric Acid → 1-(Tetrahydro-2H-pyran-4-yl)piperidin-4-amine

HRID 629593

반응식

HRID 629593 반응식
[O:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:12][CH2:11][CH:10]([NH:13]C(=O)OC(C)(C)C)[CH2:9][CH2:8]2)[CH2:3][CH2:2]1.Cl>ClCCl>[O:1]1[CH2:2][CH2:3][CH:4]([N:7]2[CH2:12][CH2:11][CH:10]([NH2:13])[CH2:9][CH2:8]2)[CH2:5][CH2:6]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 45792109tert-butyl N-[1-(oxan-4-yl)piperidin-4-yl]carbamate

생성물 1

HCID 225621451-(Tetrahydro-2H-pyran-4-yl)piperidin-4-amine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of EXAMPLE 173A (52.57 g) in dichloromethane (900 mL) was treated with 4M HCl (462 mL), mixed vigorously at room temperature for 16 hours and concentrated.

후처리

  1. additionmixed vigorously at room temperature for 16 hours
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b201bed9c4a047e2bd629fdd0012290f
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09315488B2

연결된 노트

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