Acetic Acid → 5-Acetylamino-2,3-dihydrobenzofuran

HRID 629678노트

반응식

HRID 629678 반응식
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1.[CH3:11][C:12](O)=[O:13]>CC(OC(C)=O)=O>[C:12]([NH:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1)(=[O:13])[CH3:11]

참가 물질

4

반응물 2

HCID 176Acetic AcidHCID 38411022,3-Dihydro-1-benzofuran-5-amine

생성물 1

HCID 129085765-Acetylamino-2,3-dihydrobenzofuran수율 88%

시약·촉매·용매 1

HCID 7918Acetic Anhydride용매

실험 절차

The product (5.2 g, 38.5 mmol) obtained in Step 2 was dissolved in AcOH (20 mL) and Ac2O (5 mL), heated to 60° C., reacted for 12 h, and concentrated to obtain a crude product (6 g, 88.0%).

후처리

  1. customreacted for 12 h
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-d8cd9c2594d146538e09f239e153ba7a
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09315513B2

반응 노트

불러오는 중…