Benzoyl Peroxide → 1-(Bromomethyl)-2-chloro-3-nitrobenzene

HRID 629986

반응식

HRID 629986 반응식
[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH3:11].[Br:12]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:12][CH2:11][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]=1[Cl:1]

참가 물질

5

반응물 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 775912-Chloro-3-nitrotoluene

생성물 1

HCID 183630451-(Bromomethyl)-2-chloro-3-nitrobenzene수율 47.2%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

2-chloro-1-methyl-3-nitrobenzene (1 g, 5.8 mmol) was dissolved in CCl4 (10 mL), then N-bromosuccinimide (2.28 g, 12.8 mmol) and benzoyl peroxide (846 mg, 3.5 mmol) were added. The mixture was stirred overnight at reflux. The solid was removed by filtration, and the filtrate was washed with water and dried over sodium sulfate. After evaporation of the solvent, the residue was dissolved in DCM and purified on silica gel using 30% hexane/AcOEt to afford 1-(bromomethyl)-2-chloro-3-nitrobenzene (686 mg, 47% yield); 1H NMR (400 MHz, CDCl3): δ 4.64 (s, 2H), 7.42 (t, J=7.9 Hz, 1H), 7.67 (dd, J=1.6 Hz, J=7.9 Hz, 1H), 7.75 (dd, J=1.6 Hz, J=7.9 Hz, 1H).

후처리

  1. temperatureat reflux
  2. customThe solid was removed by filtration
  3. washthe filtrate was washed with water
  4. dry with materialdried over sodium sulfate
  5. customAfter evaporation of the solvent
  6. dissolutionthe residue was dissolved in DCM
  7. custompurified on silica gel using 30% hexane/AcOEt

출처 및 근거

ORD 기록
ord-11beda3f34914e3da2669082653370b9
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09315521B2

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