Phosphorus tribromide → 2-(Bromomethyl)-1-methyl-1H-benzimidazole hydrobromide

HRID 630034

반응식

HRID 630034 반응식
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]=[C:3]1[CH2:11]O.P(Br)(Br)[Br:14]>ClCCl>[BrH:14].[Br:14][CH2:11][C:3]1[N:2]([CH3:1])[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]=1

참가 물질

4

반응물 2

HCID 24614Phosphorus tribromideHCID 344177(1-methyl-1H-1,3-benzodiazol-2-yl)methanol

생성물 1

HCID 242294512-(Bromomethyl)-1-methyl-1H-benzimidazole hydrobromide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of (1-methyl-1H-benzimidazol-2-yl)methanol (1.1 g, 6.8 mmol) in anhydrous dichloromethane (60 mL) was added dropwise phosphorus tribromide (1.3 mL, 14.0 mmol). The mixture was stirred at room temperature overnight. Dichloromethane was evaporated. The residue was dried in vacuo, affording 2-(bromomethyl)-1-methyl-1H-benzimidazole hydrobromide. The product was used without further purification.

후처리

  1. customDichloromethane was evaporated
  2. customThe residue was dried in vacuo

출처 및 근거

ORD 기록
ord-0097ecac854d44488bcbc78e8c9c1f15
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09315521B2

연결된 노트

불러오는 중…