Phosphorus tribromide → 4-(Bromomethyl)-3,5-dimethyl-1,2-oxazole

HRID 630037

반응식

HRID 630037 반응식
[CH3:1][C:2]1[C:6]([CH2:7]O)=[C:5]([CH3:9])[O:4][N:3]=1.P(Br)(Br)[Br:11]>ClCCl>[Br:11][CH2:7][C:6]1[C:2]([CH3:1])=[N:3][O:4][C:5]=1[CH3:9]

참가 물질

4

반응물 2

HCID 24614Phosphorus tribromideHCID 2895753,5-Dimethyl-4-(hydroxymethyl)isoxazole

생성물 1

HCID 127932894-(Bromomethyl)-3,5-dimethyl-1,2-oxazole

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of (3,5-dimethyl-1,2-oxazol-4-yl)methanol (805 mg, 6.3 mmol) in anhydrous dichloromethane (60 mL) was added dropwise phosphorus tribromide (1.2 mL, 12.6 mmol). The mixture was stirred at room temperature for 3 hours. Dichloromethane was evaporated, and the residue was dried in vacuo, affording 4-(bromomethyl)-3,5-dimethyl-1,2-oxazole. The product was used without further purification.

후처리

  1. customDichloromethane was evaporated
  2. customthe residue was dried in vacuo

출처 및 근거

ORD 기록
ord-c858e68f353143a8bbd0df66a64fcd0d
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09315521B2

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