Phosphorus tribromide → Benzenemethanamine, 3-(bromomethyl)-4-chloro-N,N-diethyl-

HRID 630054노트

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HRID 630054 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]([CH2:12][CH3:13])[CH2:10][CH3:11])=[CH:4][C:3]=1[CH2:14]O.P(Br)(Br)[Br:17]>ClCCl>[Br:17][CH2:14][C:3]1[CH:4]=[C:5]([CH2:8][N:9]([CH2:12][CH3:13])[CH2:10][CH3:11])[CH:6]=[CH:7][C:2]=1[Cl:1]

참가 물질

4

반응물 2

HCID 24614Phosphorus tribromideHCID 59589352HCID 59589352, 화합물

생성물 1

HCID 66815196Benzenemethanamine, 3-(bromomethyl)-4-chloro-N,N-diethyl-

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of {2-chloro-5-[(diethylamino)methyl]phenyl}methanol (3.0 g, 13.2 mmol) in anhydrous dichloromethane (80 mL) was added dropwise phosphorus tribromide (2.5 mL, 26.4 mmol). The mixture was stirred at room temperature overnight. The solvent was evaporated. The residue was dried in vacuo, affording {[3-(bromomethyl)-4-chlorophenyl]methyl}diethylamine. The product was used without further purification.

후처리

  1. customThe solvent was evaporated
  2. customThe residue was dried in vacuo

출처 및 근거

ORD 기록
ord-0c42fc26846741df9dbd7bc516541f0f
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09315521B2

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