Phosphorus tribromide → 3-(bromomethyl)-4-chloro-1-methyl-1H-pyrazole

HRID 630185노트

반응식

HRID 630185 반응식
[Cl:1][C:2]1[C:3]([CH2:8]O)=[N:4][N:5]([CH3:7])[CH:6]=1.[Br:10]P(Br)Br>ClCCl>[Br:10][CH2:8][C:3]1[C:2]([Cl:1])=[CH:6][N:5]([CH3:7])[N:4]=1

참가 물질

4

반응물 2

HCID 24614Phosphorus tribromideHCID 55255171(4-chloro-1-methyl-1H-pyrazol-3-yl)methanol

생성물 1

HCID 595893993-(bromomethyl)-4-chloro-1-methyl-1H-pyrazole

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a solution of (4-chloro-1-methyl-1H-pyrazol-3-yl)methanol (680 mg, 4.7 mmol) in anhydrous dichloromethane (25 mL) was added dropwise a solution of tribromophosphane (450 μL, 4.7 mmol) in anhydrous dichloromethane (5 mL) at 0° C. The mixture was stirred for 1 hour at room temperature and then was evaporated to yield 3-(bromomethyl)-4-chloro-1-methyl-1H-pyrazole, which was used in the next step without further purification.

후처리

  1. customwas evaporated

출처 및 근거

ORD 기록
ord-17923f3b1552404dbd7e0c0c9c30fe6e
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09315521B2

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