Phosphorus tribromide → 3-(Bromomethyl)-2-ethylpyridine
반응식
[CH2:1]([C:3]1[C:8]([CH2:9]O)=[CH:7][CH:6]=[CH:5][N:4]=1)[CH3:2].[Br:11]P(Br)Br>ClCCl>[Br:11][CH2:9][C:8]1[C:3]([CH2:1][CH3:2])=[N:4][CH:5]=[CH:6][CH:7]=1참가 물질
4
실험 절차
To a solution (2-ethylpyridin-3-yl)methanol (3.0 g, 21.9 mmol) in anhydrous dichloromethane (150 mL) was added tribromophosphane (2.3 mL, 24.2 mmol). The mixture was stirred at room temperature overnight. Dichloromethane was evaporated. The residue was dried in vacuo, affording 3-(bromomethyl)-2-ethylpyridine, which was used without further purification.
후처리
- customDichloromethane was evaporated
- customThe residue was dried in vacuo
출처 및 근거
- ORD 기록
- ord-456f50252fa3489d8226f630f1527545
- 출처 데이터셋
- uspto-grants-2016_04
- 특허 번호
- US09315521B2
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