Phosphorus tribromide → HCID 66815164, 화합물
반응식
[CH2:1]([C:3]1[CH:4]=[N:5][CH:6]=[C:7]([F:11])[C:8]=1[CH2:9]O)[CH3:2].[Br:12]P(Br)Br>ClCCl>[BrH:12].[Br:12][CH2:9][C:8]1[C:7]([F:11])=[CH:6][N:5]=[CH:4][C:3]=1[CH2:1][CH3:2]참가 물질
4
실험 절차
To a solution of (3-ethyl-5-fluoropyridin-4-yl)methanol (1.5 g, 9.7 mmol) in anhydrous dichloromethane (75 mL) was added tribromophosphane (1 mL, 10.5 mmol). The mixture was stirred at room temperature overnight. Dichloromethane was evaporated. The residue was dried in vacuo, affording 4-(bromomethyl)-3-ethyl-5-fluoropyridine hydrobromide. The crude product was used without further purification.
후처리
- customDichloromethane was evaporated
- customThe residue was dried in vacuo
출처 및 근거
- ORD 기록
- ord-936ee85f32c7401d9009971e0c5ace2d
- 출처 데이터셋
- uspto-grants-2016_04
- 특허 번호
- US09315521B2
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